Quantcast
Published On: Fri, Dec 20th, 2013

Research findings could result in the development of a vaccine and drugs for mucormycosis

PRESS RELEASE

Mucormycosis is a deadly infection that strikes people with weakened immune systems when certain types of fungi, called Mucorales, invade the patients’ cells. A novel protein on the surface of the Mucorales cells, called CotH, makes this invasion possible. 

Mucor Image/CDC

Mucor
Image/CDC

In a finding that could lead to the development of a vaccine and therapies for mucormycosis, a research team at Los Angeles Biomedical Research Institute (LA BioMed) reported today in an online, ahead-of-print study in the Journal of Clinical Investigation that they can prevent human cell invasion and successfully treat mucormycosis in disease models using antibodies that block the CotH protein. 

“There are no vaccines or effective therapies available today to halt the highly fatal mucormycosis infection, and there is an urgent need for these strategies to protect patients with weakened immune systems,” said Ashraf S. Ibrahim, PhD, an LA BioMed lead researcher and corresponding author for the study. “Our research lays the groundwork for developing the antibodies to prevent and treat mucormycosis in high-risk patients. These findings also could lead to diagnostic tests for the disease.”

Patients with weakened immune systems, malnutrition or acidosis (hyperglycemia or diabetic ketoacidosis) are at increased risk of infection. Dr Ibrahim’s group found treatment with anti-CotH antibodies or CotH-targeted RNAi blocked the cell invasion and protected against mucormycosis.

Founded in 1952, LA BioMed is one of the country’s leading nonprofit independent biomedical research institutes. It has approximately 100 principal researchers conducting studies into improved diagnostics and treatments  for cancer, inherited diseases, infectious diseases, illnesses caused by environmental factors and more. It also educates young scientists and provides community services, including prenatal counseling and childhood nutrition programs. LA BioMed is academically affiliated with the David Geffen School of Medicine at UCLA and located on the campus of Harbor-UCLA Medical Center. For more information, please visit www.LABioMed.org

For more infectious disease news and information, visit and “like” the Infectious Disease News Facebook page and the Outbreak News This Week Radio Show page.

Looking for a job in health care? Check here to see what’s available

On the DISPATCH: Headlines  Local  Opinion

Subscribe to Weekly Newsletter

* indicates required
/ ( mm / dd ) [ALL INFO CONFIDENTIAL]

About the Author

- Writer, Co-Founder and Executive Editor of The Global Dispatch. Robert has been covering news in the areas of health, world news and politics for a variety of online news sources. He is also the Editor-in-Chief of the website, Outbreak News Today and hosts the podcast, Outbreak News Interviews on iTunes, Stitcher and Spotify Robert is politically Independent and a born again Christian Follow @bactiman63

Tags

Leave a comment

XHTML: You can use these html tags: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

Sign up for our Weekly Newsletter



Categories

Archives

At the Movies

Pin It