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Published On: Mon, Feb 24th, 2014

Recent developments in Herpes Simplex Virus (HSV-2) therapeutics look promising

In the past two months, new therapies for the prevention and treatment of Herpes Simplex Virus (HSV-2)  have showed some promising results.

In January, a study published in the New England Journal of Medicine showed the results of an experimental drug, Pritelivir, and it’s antiviral activity.

Herpes simplex virions  Image/CDC

Herpes simplex virions Image/CDC

The relatively small study (156 HSV-2–positive persons), “Helicase–Primase Inhibitor Pritelivir for HSV-2 Infection” revealed that Pritelivir substantially reduced the rates of genital HSV shedding, which basically translates to decreased virus activity and possibility for transmission.

Although the study is considered preliminary, researchers say pritelivir works differently from existing drugs and it could eventually prove to be better  at preventing transmission of the virus.

In fact, Dr. Richard Whitley, an infectious disease expert at the University of Alabama at Birmingham said, “We’re at the beginning of a new era” in genital herpes treatment.

Does having genital herpes have you feeling like no one understands you? Believe me, you are not alone, there are thousands of people just like you, and you can meet them at the #1 community for STD dating and support, PositiveSingles.com.

Earlier this month, Australian company,  Admedus announced  its therapeutic vaccine for Herpes Simplex Virus (HSV-2) has proven to be safe and able to  generate a T-cell response in early results in Phase 1 clinical trials.

The dosing of study subjects was completed in December 2013 and further analysis of the data in still ongoing.

“This is an encouraging result for the core vaccine technology and provides us with the basis for not only progressing the Herpes therapeutic vaccine program, but also preparing the Human Papillomavirus vaccine for initial clinical studies as a therapeutic against HPV and Cervical Cancer,” chief executive officer Lee Rodne said.

Professor Ian Frazer, a former Australian of the Year and developer of the HPV vaccine,  developed the experimental vaccine with his team at Coridon, a biotechnology company he founded in 2000.

Admedus, who is funding the vaccine development, announced the early results of the trial to the Australian Stock Exchange on Feb.3.

Proactive Investors Australia reports:

Coridon’s Herpes therapeutic vaccine seeks to stimulate the body’s immune system to produce T-cells – a type of antibody – targeting the virus. The trial was undertaken by Professor Frazer and his team in Brisbane on five cohorts with four participants in each cohort.

Each participant received three doses via intradermal injection during the study, which is focused primarily on safety.

All participants were screened to exclude previous exposure to Herpes simplex virus 1 (cold sores) or HSV-2 (genital herpes on the rationale that they would have no antibodies or T cells targeting the virus.

The results will also provide an early indicator of the vaccine’s ability to generate an effective immune response.

If the vaccine is able to stimulate the person’s immune system such that it is being able to generate antibodies and T-cells against the herpes virus, without actually ever being infected, it would mean that it is safe and able to activate the immune system against the virus.

This would likely prevent future herpes infections and could also clear up the virus.

In Nov. 2103, the  National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), announced the launch of phase 1 clinical trials into an investigational genital herpes vaccine called HSV529.

Genital herpes is a sexually transmitted disease (STD) caused by the herpes simplex viruses type 1 (HSV-1) or type 2 (HSV-2).

According to CDC estimates, 776,000 people in the United States get new herpes infections annually.

Genital herpes infection is common in the United States. Nationwide, 16%, or about one out of six, people aged 14 to 49 years have genital HSV-2 infection. Over the past decade, the percentage of persons with genital herpes infection in the United States has remained stable.

People get herpes by having sex with someone who has the disease. “Having sex” means anal, vaginal, or oral sex.

There is no treatment that can cure herpes. Antiviral medications can, however, prevent or shorten outbreaks during the period of time the person takes the medication.  In addition, daily suppressive therapy (i.e., daily use of antiviral medication) for herpes can reduce the likelihood of transmission to partners.

With nearly 800,000 members, PositiveSingles.com is the place to be for singles and friends with STDs. As the most trusted and anonymous online dating site in the world for people with herpes, HPV, HIV and every other STD, PositiveSingles.com is the community where can get on with your life and meet new friends, partners or potential spouses. Information about STD medical treatments and information is available, and there is always someone to talk to or offer help and advice and they really understand because they walk in your shoes.

 

 

 

 

 

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About the Author

- Writer, Co-Founder and Executive Editor of The Global Dispatch. Robert has been covering news in the areas of health, world news and politics for a variety of online news sources. He is also the Editor-in-Chief of the website, Outbreak News Today and hosts the podcast, Outbreak News Interviews on iTunes, Stitcher and Spotify Robert is politically Independent and a born again Christian Follow @bactiman63

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  5. Maria Lopez says:

    Herpes Virus is a terrible virus, if not for my Husband and the help of the great Dr. Ehi my life would have been a mess! I was diagnose with Herpes virus in 2014, my husband encouraged me, and told me not to lose hope, I manage to give birth to a baby Boy who was free from this virus, and my Husband was always there for me! One day he came to me and told me that he have found a man who can cure me. Base on scientist, they said there is no cure for Herpes virus; he told me that he has seen many testimonies about him on the Internet. We decided to contact him, we filled his Herbal home form, and he asked us to buy some local root and herbs items which we did! and he prepared for me a herbal medicine and 14 days later he asked me to go for medical test, faithfully hopefully i went for the medical test, and Behold, I was cured, from this virus and its was not found in my Body system again… My Dear Husband and my Father Dr. Ehi, God will surely bless the both of you, till the end of time, in Jesus name.. If you have any problem kindly contact Dr Ehi via his email ([email protected]) or WhatsApp him on +2349035080936.

  6. Oliver says:

    Guarantee there’s a cure for herpes and either the government or drug companies have it hidden. Why cure it for $100 when you can treat it for thousands?
    there isn’t any cure yet for herpes, still I think the people with STD’s can have support from the online support groups such as http://www.herpesdatingsite.biz , this website has more than 1000,000 users worldwide,its the community where you can get on with your life and meet new friends, partners or potential spouses.

  7. Michh Moriss says:

    Herpes is spreading very swiftly and we should take a stand to stop it, First step is to date only Herpes singles from sites like http://www.herpesdatinglife.com/.

  8. Emma Jose says:

    Yes, there isn’t any cure yet for herpes, still I think the people with STD’s can have support from the online support groups such as http://www.MPWHerpes.com, this website has more than 800,000 users worldwide,its the community where you can get on with your life and meet new friends, partners or potential spouses.

    • Abby says:

      Yes, Herpes is spreading very swiftly and we should take a stand to stop it, still I think the people with STD’s can have support from the online support groups such as http://www.herpesdatingsites.org/ , this website has more than 1000,000 users worldwide,its the community where you can get on with your life and meet new friends, partners or potential spouses.

  9. MAC says:

    Promising information, how many more years do to come before a cure can be found

  10. Linda says:

    Very nice information. I found it very useful and enlightening.

  11. josh says:

    Thanks for sharing.It is very useful for me.

  12. Lilly says:

    Guarantee there’s a cure for herpes and either the government or drug companies have it hidden. Why cure it for $100 when you can treat it for thousands?

  13. adrienne says:

    can u send me more info on this drug??? I have tested positive 4 HSV at the age 15 now im 34 although I haven’t been tested n yrs, I still have mild outbreaks. I need some info on the best medication possible!!!

  14. Recent developments in Herpes Simplex Virus (HSV-2) therapeutics look … – The Global Dispatch | Sex dating says:

    […] The Global Dispatch […]

  15. erika rasmussen says:

    read more about this and how the research is an actual cure… on the market… right now!

    http://www.viradux.com

    • rhonda greyers says:

      Erika, I think you are doing a service by spreading the word on Viradux. I began using it last year and have been HSV negative since. One question, how long before you discontinued use? I am still using it just to be caution. The company told me I could stop now. But I am paranoid it will come back, although others tell me that can never happen. Thanks!

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