Quantcast
Published On: Mon, May 6th, 2013

Pregnant women warned to avoid Depakote, Depacon and Depakene for migraines: Can cause decreased IQ in children

The U.S. Food and Drug Administration (FDA) is warning physicians, other health care providers and pregnant women to avoid medications containing valproate products as this can cause lower IQ scores in children of mothers who used them during pregnancy, according to an FDA news release today.

Image/James Gathany

Image/James Gathany

Valproate products are approved in the treatment of  epilepsy (seizures), prevention of migraine headaches and treatment of manic episodes associated with bipolar disorder (manic-depressive disorder).

Examples of drugs containing valproate include valproate sodium (Depacon), divalproex sodium (Depakote, Depakote CP, and Depakote ER), valproic acid (Depakene and Stavzor), and their generics. These these drugs are being contraindicated for (should never be used by) pregnant women for the prevention of migraine headaches.

Valproate medications should never be used in pregnant women for the prevention of migraine headaches because we have even more data now that show the risks to the children outweigh any treatment benefits for this use,” said Russell Katz, M.D., director of the Division of Neurology Products in the FDA’s Center for Drug Evaluation and Research.

The FDA’s strengthened recommendations are based on the final results of the NEAD study, which showed that children exposed to valproate products in utero had decreased IQ at age 6 when compared to children who were exposed to other antiepileptic drugs. The difference in average IQ between the children who had been exposed to valproate and the children who had been exposed to other antiepileptic drugs varied between 8 and 11 points depending on the antiepileptic drug.

For its other approved uses — bipolar disorder and seizures — valproate may have some value in pregnant women, but it should only be taken if other medications have not controlled the symptoms or are otherwise unacceptable. Women who can become pregnant should not use valproate unless it is essential to managing their medical condition.

Looking for a job in health care? Check here to see what’s available

 

 

On the DISPATCH: Headlines  Local  Opinion

Subscribe to Weekly Newsletter

* indicates required
/ ( mm / dd ) [ALL INFO CONFIDENTIAL]

About the Author

- Writer, Co-Founder and Executive Editor of The Global Dispatch. Robert has been covering news in the areas of health, world news and politics for a variety of online news sources. He is also the Editor-in-Chief of the website, Outbreak News Today and hosts the podcast, Outbreak News Interviews on iTunes, Stitcher and Spotify Robert is politically Independent and a born again Christian Follow @bactiman63

Tags
Displaying 1 Comments
Have Your Say
  1. Pfizer to sell Viagra online, you’ll still … | says:

    […] […]

Leave a comment

XHTML: You can use these html tags: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

Sign up for our Weekly Newsletter



Categories

Archives

At the Movies

Pin It