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Published On: Wed, Dec 26th, 2012

Orphan drug, Juxtapid gets FDA approval for treating HoFH

The Global Dispatch 294x150The US Food and Drug Administration announced the approval of Juxtapid (lomitapide), a new orphan drug used to reduce cholesterol in patients with the rare disorder, homozygous familial hypercholesterolemia (HoFH), according to an FDA news release Wednesday.

The drug is manufactured by Cambridge, Mass.-based Aegerion Pharmaceuticals Inc.

The once-a-day capsule, used in conjunction with a low fat diet and other lipid-lowering treatments, is used to reduce low-density lipoprotein (LDL) cholesterol, total cholesterol, apolipoprotein B, and non-high-density lipoprotein (non-HDL) cholesterol in patients with the rare (approximately one in one million Americans) cholesterol disorder.

“Juxtapid, in addition to diet changes and other cholesterol-lowering treatments, is a new option for those suffering with HoFH and the serious health consequences resulting from this condition,” said Eric Colman, M.D., deputy director of the Division of Metabolism and Endocrinology Products in the FDA’s Center for Drug Evaluation and Research.

According to the FDA, HoFH is a rare inherited condition that makes the body unable to remove LDL cholesterol, often called the “bad” cholesterol, from the blood, causing abnormally high levels of circulating LDL cholesterol.

For those with HoFH, heart attacks and death often occur before age 30. Juxtapid works by impairing the creation of the lipid particles that ultimately give rise to LDL.

The most common adverse reactions in the clinical trial included diarrhea, nausea, vomiting, indigestion, and abdominal pain.

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About the Author

- Writer, Co-Founder and Executive Editor of The Global Dispatch. Robert has been covering news in the areas of health, world news and politics for a variety of online news sources. He is also the Editor-in-Chief of the website, Outbreak News Today and hosts the podcast, Outbreak News Interviews on iTunes, Stitcher and Spotify Robert is politically Independent and a born again Christian Follow @bactiman63

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  1. FDA OKs Drug for Rare Lipid Disorder – MedPage Today says:

    […] lowering drugUPI.comJuxtapid earns FDA approval in homozygous familial hypercholesterolemiaHealioThe Global Dispatch -Patch.com -Fox Newsall 150 news […]

  2. Drug for ultrarare lipid disorder OK’d by FDA – Medical Marketing and Media | Weight Loss Diet Plan says:

    […] for Cholesterol DrugMinyanville.comAegerion Gets Approval for Cholesterol DrugWall Street JournalThe Global Dispatch -Medscape -Businessweekall 145 news […]

  3. FDA Approves New Orphan Drug For Rare Cholesterol Disorder – Patch.com | Weight Loss Diet Plan says:

    […] lipoprotein (LDL) cholesterol, total cholesterol, apolipoprotein B, and non-high-density …Orphan drug, Juxtapid gets FDA approval for treat…The Global DispatchAegerion Gets Approval for Cholesterol DrugWall Street JournalLomitapide Approved […]

  4. FDA OKs Drug for Rare Lipid Disorder – MedPage Today | Health News says:

    […] TreatmentRTT NewsJuxtapid earns FDA approval in homozygous familial hypercholesterolemiaHealioThe Global Dispatch -Fox News -Businessweekall 148 news […]

  5. FDA OKs Drug for Rare Lipid Disorder – MedPage Today | ExcellentHealthNews.com says:

    […] TreatmentRTT NewsJuxtapid earns FDA approval in homozygous familial hypercholesterolemiaHealioThe Global Dispatch -Fox News -Businessweekall 148 news […]

  6. XUSIE » Drug for ultrarare lipid disorder OK’d by FDA – Medical Marketing and Media says:

    […] for Cholesterol DrugMinyanville.comAegerion Gets Approval for Cholesterol DrugWall Street JournalThe Global Dispatch -Medscape -Businessweekall 145 news […]

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