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Published On: Thu, Jun 26th, 2014

Virginia Tech researchers develop chromosome map for Aedes aegypti, compare to Anopheles for disease prevention

Virginia Tech entomologists have developed a chromosome map for about half of the genome of the mosquito Aedes agypti, the major carrier of dengue fever and yellow fever. 

A female Aedes aegypti mosquito Image/CDC

A female Aedes aegypti mosquito
Image/CDC

With the map, researchers can compare the chromosome organization and evolution between this mosquito and the major carrier of malaria, the Anopheles gambiae mosquito, to find ways to prevent diseases.

“Despite looking somewhat similar, these mosquitoes diverged from each other about 150 million years ago. So, they are genetically further apart than humans and elephants,” said Maria Sharakhova, a research scientist in the College of Agriculture and Life Sciences, a Fralin Life Science Institute affiliate, and the principal investigator of the study published in BMC Biology and highlighted on Biome.

The researchers say that the genome of the malaria mosquito is clearly separated into gene-rich and gene-poor compartments, while the genome of the yellow fever mosquito has no such differentiation. The study supports the observation that sex determination is also handled differently in the two mosquito species which could be useful in devising prevention measures. 

In the malaria mosquito, X and Y chromosomes determine sex, but in the yellow fever mosquito, sex in males is determined just by a small location on chromosome 1. 

Read the rest of the Virginia Tech news release

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